部分液體通氣治療重癥COVID-19

Request professional help for tralation into English.大家好：我提供一點(diǎn)建議，目前呼吸機(jī)短缺的主要原因一方面是病人數(shù)量驟增，形成醫(yī)療資源擠兌，另一方面不得不說(shuō)，現(xiàn)在的高流氧治療方案搶救成功率低。因此我們提議以目前用于救治早產(chǎn)兒的液體介質(zhì)呼吸用于治療重型和危重型COVID-19。從文獻(xiàn)了解，液體通氣可以通過(guò)清除粘液阻塞來(lái)幫助增加氧氣的吸收，改善通氣 / 血流比值,改善機(jī)體氧合狀況。局部消炎作用，在體外抑制肺泡巨噬細(xì)胞對(duì)異物的反應(yīng)性。重型和危重型COVID-19患者的肺部被病毒導(dǎo)致的果凍狀的分泌物占據(jù)，換氣功能完全喪失，高壓力流氧方案不能去除黏液，很多時(shí)候還會(huì)導(dǎo)致病情加重。液體介質(zhì)呼吸治療方案以PFC為通氣介質(zhì)，通過(guò)霧化或汽化吸入通氣干預(yù)呼吸衰竭的過(guò)程。具體方法是在常規(guī)機(jī)械通氣基礎(chǔ)上，經(jīng)呼吸機(jī)吸氣管路以濕化器加熱 PFC 的方法給予汽化吸入 PFC 治療 2 小時(shí)，然后繼續(xù)常規(guī)機(jī)械通氣 6 小時(shí)。為了提高治療效果，綜合采用包括肺保護(hù)性通氣、肺復(fù)張、俯臥位通氣等通氣策略。如果臨床治療有效，將極大提高呼吸機(jī)的利用率，部分解決呼吸機(jī)短缺問(wèn)題。With cases of the new coronavirus disease 2019 (COVID-19) climbing steeply everywhere from Madrid to Manhattan , overwhelming one hospital after another and pushing the global death toll past 23,000, the sprint to find treatments has dramatically accelerated. The World Health Organization (WHO) last week announced a major study to compare treatment strategies in a streamlined clinical trial design that docto around the world can join. Other trials are also underway; all told, at least 12 potential COVID-19 treatments are being tested, including drugs already in use for HIV and malaria, experimental compounds that work agait an array of viruses in animal experiments, and antibody-rich plasma from people who have recovered from COVID-19. More than one strategy may prove its worth, and effective treatments may work at different stages of infection, says Thomas Gallagher, a coronavirus researcher at Loyola Univeity Chicago's Health Sciences severe cases of COVID-19 a patient’s lungs become inflamed and filled with fluid which makes it difficult for them to breathe. in these cases hyperoxia therapy get low rescue success breathing is a form of respiration in which a normally air-breathing organism breathes an oxygen-rich liquid (such as a perfluorocarbon), rather than breathing air, include Total liquid ventilation and Partial liquid ventilation(PLV).Liquid breathing could assist in the treatment of patients with severe pulmonary or cardiac trauma, especially in pediatric cases. PFC emulsio could prove an effective new way to eliminate inflammation and mucus during the drug delivery process, decreasing the risk of chronic infection while increasing the patient’s ability to breathe deeply. Liquid ventilation, minus the drugs, is already seeing use in neonatal units on premature infants with underdeveloped lungs. The method has even been coidered as an alternative to intravenous (IV) drug delivery in some itances. Unlike IV delivery, drugs delivered through the lungs bypass the fit pass through the liver, which can often filter much of the medication from the blood before it has a chance to reach the rest of the body. live we need to breathe. Prior to being born we carry this activity out through the placenta and subsequently by mea of our lungs. ation of science fiction respiration respirator simulates placentary respiration by filling the lungs of the premature baby with liquid and then the respirator introduces and extracts the required quantity of liquid at a suitable respiratory rhythm.